Pathology III Quiz #2 Hypertrophic Cardiomyopathy

Other names for HCM
Idiopathic hypertrophic sub-aortic stenosis
Hypertrophic obstructive cardiomyopathy

Characterizations of HCM
Myocardial hypertrophy
Abnormal diastolic filling
1/3 of cases intermittent ventricular outflow obstruction

Microscopic components of HCM
Hypertrophy of myocardial fibers w/ prominent dark nuclei, interstitial fibrosis

Etiology
Genetic dz
Mutation in any one of several genes that encode proteins within the sarcomere

Essential feature of HCM
Massive myocardial hypertrophy w/o ventricular dilation

Disproportionate thickening occurs between these
Ventricular septum becomes disproportionately thicker than the free wall of the ventricle

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