Pathology- Rabies and Epidemiology

oldest recorded disease

discovered by


rabies location
nervous tissue, saliva, salivary glands, pancreas, lesser urine, lymph, blood, milk

no, virus can still survive

deadly environment for rabies
dried saliva, inactivated by sunlight and boiling

rabies vectors
bats, skunks, raccoons, foxes

exposure and clinical disease
not always

bite wound, mm, cuts/wounds

incubation period
up to 6mo, as short as 10 days

secreted in saliva when
reaches brain

signs of rabies
acute infectious encephalitis, altered behavior, aggression, paralysis, death

phases of rabies
prodromal, excitatory(furious), paralytic(dumb)

prodromal phase signs
mydriasis, slow corneal reflex, increased temp

paralytic phase signs
paralytic(herbivores), thin, depressed, unable to eat/drink, drooling, protrusion of the tongue and nictitating membrane

excitatory phase signs
1-7 days, chewing, biting, aggression, self mutilation, laryngeal paralysis-unable to swallow, drooling, foaming, changed vocalization, convulsions, incoordination

diagnostic test
fluorescent antibodies

cell inclusion seen in cytoplasm
negri bodies

vector that rabies causes most death from

immunization requirements
dog, cat if rabies in country

w/in 3-5 days of exposure

disease transmissible under natural conditions between vertebrate animals and humans

individual infected without overt signs of disease
carrier host

vertebrate animal where the agent persists in nature

zoonotic agents
nematodes, trematodes, cestodes, protozoa, fungi, gram negative and positive bacteria, spirochetes, rickettsia, dna and rna viruses

first herd recognized case of disease
index case

international outbreak

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