Cancer Drugs Pharmacology ORU nursing 2012

Cytoxan (cyclophsophamide)
aklylating agent, hemorrhagic cystitis (must empty bladder frequently, pulmonary toxicity, keep hydrated

Cisplatin
Platin, cumulative kidney disfunction, hearing loss, hold if creatine < 1.5, vesicant (tissue necrosis)

Carboplatin
Platin, dose based on creatine, hypersensitivity after 7 doses

5-fluorouracil
antimetabolites, mucositis (ice chips), hair loss, photosensitvity

Methotraxate (MTX)
antimetabolites, neurotoxicity, mucositis, renal/liver toxic, photosensitivity

Bleomycin
antineoplastic antibiotic, pulmonary fibrosis, hair loss, hyperpigmentation, fever/chills

Doxorubicin (adriamy)
antineoplastic antibiotic, cumulative cardiac toxicity, mucositis, hair loss, red urine

Taxol/Taxatere
mitotic inhibitor

taxanes
yew tree, allergic reactions, peripheral neuropathy

Vincristine
plant alkaloids, numbness, reflex loss, constipation, hair loss, jaw pain

Vinblastine
plant alkaloids, numbness, BMS, loss of reflex, constipation, hair loss

Dexamethasone
Hormonal therapy

Methylprednisolone (Solu-medrol)
Hormonal Therapy

Prednisone
Hormonal Therapy, myeloma, lymphoma

Tamoxifen
Antiestrogen agent

Aromatase inhibitor (arimidex)
antiestrogen agent

Triptorelin (Telstar)
anti androgenic

Casodex
anti androgenic

Lupron
anti androgenic (1-3 mo)

Megase
Hormone therapy, synthetic progestin, manage anorexia, weight loss in AIDs

Interferons
inhibit cellular replication, fever/chills, hep C, kaposi sarcoma, leukemia, depression suicide

Interleukins
Biological therapy, B and T cell recruitment, Melanoma, 3rd space of fluid (Albumin, dehydrated)

Epogen, Procrit, Aranesp
RBC stimulator

Neupogen, Neulasta
WMB stimulator

Reclast, Actonel, Fosamax, Boniva
Supportive drugs

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